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Chemical Structure : TIM-098a
Catalog No.: PC-22031Not For Human Use, Lab Use Only.
TIM-098a is a potent, selective AP2-associated protein kinase 1 (AAK1) with IC50 of 0.24 uM, inhibits AAK1 activity in transfected cultured cells with IC50 of 0.87 uM.
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TIM-098a is a potent, selective AP2-associated protein kinase 1 (AAK1) with IC50 of 0.24 uM, inhibits AAK1 activity in transfected cultured cells with IC50 of 0.87 uM.
TIM-098a displays 4–30-fold selectivity over other NAKs, including GAK, BIKE, and STK16.
TIM-098a (10 uM) suppresses the AAK1-regulated clathrin-dependent endocytosis in HeLa cells.
| M.Wt | 301.31 | |
| Formula | C18H11N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Akari Yoshida, et al. Sci Rep. 2024 Mar 20;14(1):6723.
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