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Chemical Structure : TIM-3 inhibitor A-41
Catalog No.: PC-21023Not For Human Use, Lab Use Only.
TIM-3 inhibitor A-41 is small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with SPR Kd value of 0.61 uM.
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TIM-3 inhibitor A-41 is small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with SPR Kd value of 0.61 uM.
TIM-3 inhibitor A-41 displays minimal inhibitory profile against a panel of immune checkpoints, including PD-1, CTLA4, LAG-3, VISTA, and TIGIT.
TIM-3 inhibitor A-41 demonstrates a remarkable ability to block TIM-3/CEACAM1 and TIM-3/PtdSer interactions at submicromolar concentrations, blocks the TIM-3/Gal-9 interaction in a cellular platform at 1 μM.
TIM-3 inhibitor A-41 decreases the proliferation of THP-1 cells in a similar pattern to anti-TIM-3 mAb.
TIM-3 inhibitor A-41 rescues IFNγ (interferon γ) release from peripheral blood mononuclear cells (PBMCs) inhibited by recombinant TIM-3.
TIM-3 inhibitor A-41 (5 uM) potentiates the ability of PBMCs to significantly inhibit the proliferation of Kasumi-1 cells (AML cell line) in the PBMCs/Kasumi-1 coculture assay.
| M.Wt | 461.47 | |
| Formula | C25H23N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Abdel-Rahman SA, et al. J Med Chem. 2023 Aug 11. doi: 10.1021/acs.jmedchem.3c00960.
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