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Chemical Structure : TKDC
CAS No.: 425666-42-8
Catalog No.: PC-60942Not For Human Use, Lab Use Only.
TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $258 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively.
TKDC maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively.
TKDC decreases immobility and induces antidepressant-like effects in mice.
| M.Wt | 378.871 | |
| Formula | C18H19ClN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-chlorophenyl)-N-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl)methanesulfonamide |
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1. Luo Q, et al. Nat Commun. 2017 Aug 29;8(1):378.
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