Chemical Structure : TL13-112
CAS No.:
2229037-19-6
TL13-112
(TL 13-112)
Catalog No. : PC-35152Not For Human Use, Lab Use Only.
TL13-112 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of LDK378 and the cereblon ligand pomalidomide.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-3515201
Biological Activity
TL13-112 is a novel Anaplastic Lymphoma Kinase (ALK )-PROTAC developed through conjugation of LDK378 and the cereblon ligand pomalidomide.
Physicochemical Properties
M.Wt
1002.582
Formula
C49H60ClN9O10S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)-amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)-piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
References
1. Powell CE, et al. J Med Chem.
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