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TL13-112

Chemical Structure : TL13-112

CAS No.: 2229037-19-6

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TL13-112 (TL 13-112)

Catalog No.: PC-35152Not For Human Use, Lab Use Only.

TL13-112 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of LDK378 and the cereblon ligand pomalidomide.

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5 mg $498 In stock
10 mg $758 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TL13-112 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of LDK378 and the cereblon ligand pomalidomide.
TL13-112 also promotes the degradation of additional kinases including PTK2 (FAK), Aurora A, FER, and RPS6KA1 (RSK1).

Physicochemical Properties

M.Wt 1002.582
Formula C49H60ClN9O10S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)-amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)-piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

References

1. Powell CE, et al. J Med Chem. 2018 May 10;61(9):4249-4255.

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