Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-ADCs and PROTACs-PROTAC-TL13-12
TL13-12

Chemical Structure : TL13-12

CAS No.: 2229037-04-9

Add to Favorites

TL13-12 (ALK PROTAC TL13-12)

Catalog No.: PC-35151Not For Human Use, Lab Use Only.

TL13-12 is a potent anaplastic Lymphoma Kinase (ALK)-PROTAC degrader with DC50 of 10 nM in in H3122 cells.

Packing Price Stock Quantity
5 mg $258 In stock
10 mg $398 In stock
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TL13-12 is a potent anaplastic Lymphoma Kinase (ALK)-PROTAC degrader with DC50 of 10 nM in  in H3122 cells.
TL13-12 also promotes the degradation of additional kinases including PTK2 (FAK), Aurora A, FER, and RPS6KA1 (RSK1).

Physicochemical Properties

M.Wt 961.489
Formula C45H53ClN10O10S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)-amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

References

1. Powell CE, et al. J Med Chem. 2018 May 10;61(9):4249-4255.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: