Catalog No.: PC-38251Not For Human Use, Lab Use Only.
GPR39 agonist Cpd1324 (TM-N1324) is a potent, selective, orally active GPR39 agonist, activats human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.
GPR39 agonist Cpd1324 (TM-N1324) is a potent, selective, orally active GPR39 agonist, activats human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.
GPR39 agonist Cpd1324 (TM-N1324) shows clean off-target activities using a panel of 165 GPCRs, i.e., the Millipore GPCR-profiler service, and has similar potencies on murine GPR39 (180 nM and 5 nM, in the absence and presence of Zn2+).
GPR39 agonist Cpd1324 increased GLP-1 secretion in the mice as well as in mouse and human intestinal organoids, but not in GPR39 KO mouse organoids.
