Catalog No.: PC-21332Not For Human Use, Lab Use Only.
TM5441 is a specific, orally active, small molecule inhibitor of plasminogen activator inhibitor 1 (PAI-1, Serpin E1), TM5441 is as effective as complete deficiency of PAI-1 in protecting against L-NAME-induced pathologies.
TM5441 is a specific, orally active, small molecule inhibitor of plasminogen activator inhibitor 1 (PAI-1, Serpin E1), TM5441 is as effective as complete deficiency of PAI-1 in protecting against L-NAME-induced pathologies. TM5441 does not inhibit other SERPINs such as antithrombin III and α2-antiplasmin. TM5441 reduces cardiac hypertrophy derived from L-NAME treatment and prevents the development of periaortic fibrosis. TM5441 protects against L-NAME-induced vascular senescence in vivo.
