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Chemical Structure : TM5441
CAS No.: 1190221-43-2
Catalog No.: PC-21332Not For Human Use, Lab Use Only.
TM5441 is a specific, orally active, small molecule inhibitor of plasminogen activator inhibitor 1 (PAI-1, Serpin E1), TM5441 is as effective as complete deficiency of PAI-1 in protecting against L-NAME-induced pathologies.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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TM5441 is a specific, orally active, small molecule inhibitor of plasminogen activator inhibitor 1 (PAI-1, Serpin E1), TM5441 is as effective as complete deficiency of PAI-1 in protecting against L-NAME-induced pathologies.
TM5441 does not inhibit other SERPINs such as antithrombin III and α2-antiplasmin.
TM5441 reduces cardiac hypertrophy derived from L-NAME treatment and prevents the development of periaortic fibrosis.
TM5441 protects against L-NAME-induced vascular senescence in vivo.
| M.Wt | 428.83 | |
| Formula | C21H17ClN2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-Chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid |
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1. Boe AE, et al. Circulation. 2013 Nov 19;128(21):2318-24.
2. Eren M, et al. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7090-5.
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