TM5614 is a specific plasminogen activator inhibitor-1 (PAI-1) inhibitor with an IC50 value of 3.63 μM in a tPA-dependent hydrolysis assay.
TM5614 treatment significantly suppressed cell proliferation and induced apoptosis in K562/PAI-1 cells, accompanied by increased activity of Furin protease, which is a known target of PAI-1.
TM5614 significantly ameliorates PM(2.5)-induced vascular thrombosis.
TM5614 ameliorates hypophosphatemia in Hyp mice.
