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Chemical Structure : TM5614
Catalog No.: PC-22551Not For Human Use, Lab Use Only.
TM5614 is a specific PAI-1 inhibitor with an IC50 value of 3.63 μM in a tPA-dependent hydrolysis assay.
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TM5614 is a specific PAI-1 inhibitor with an IC50 value of 3.63 μM in a tPA-dependent hydrolysis assay.
TM5614 treatment significantly suppressed cell proliferation and induced apoptosis in K562/PAI-1 cells, accompanied by increased activity of Furin protease, which is a known target of PAI-1.
TM5614 significantly ameliorates PM(2.5)-induced vascular thrombosis.
TM5614 ameliorates hypophosphatemia in Hyp mice.
| M.Wt | 402.83 | |
| Formula | C23H15ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nagahisa Yamaoka, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):809-813.
2. Qian C, et al. FEBS Open Bio. 2024 Feb;14(2):290-299.
3. Sasaki K, et al. Tohoku J Exp Med. 2022 Jun 25;257(3):211-224.
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