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TM5614 sodium

Chemical Structure : TM5614 sodium

CAS No.: 1247823-40-0

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TM5614 sodium

Catalog No.: PC-22552Not For Human Use, Lab Use Only.

TM5614 sodium is a specific PAI-1 inhibitor with an IC50 value of 3.63 μM in a tPA-dependent hydrolysis assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TM5614 sodium is a specific PAI-1 inhibitor with an IC50 value of 3.63 μM in a tPA-dependent hydrolysis assay.
TM5614 treatment significantly suppressed cell proliferation and induced apoptosis in K562/PAI-1 cells, accompanied by increased activity of Furin protease, which is a known target of PAI-1.
TM5614 significantly ameliorates PM(2.5)-induced vascular thrombosis.
TM5614 ameliorates hypophosphatemia in Hyp mice.

Physicochemical Properties

M.Wt 424.82
Formula C23H14ClN2NaO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium 5-chloro-2-(3-(quinolin-8-yl)benzamido)benzoate

References

1. Nagahisa Yamaoka, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):809-813.

2. Qian C, et al. FEBS Open Bio. 2024 Feb;14(2):290-299.

3. Sasaki K, et al. Tohoku J Exp Med. 2022 Jun 25;257(3):211-224.

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