TMC-126 | HIV protease inhibitor | Probechem Biochemicals

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Chemical Structure : TMC-126

TMC-126 (UIC-94003, TMC126)

Catalog No.: PC-26785Not For Human Use, Lab Use Only.

TMC-126 (UIC-94003) is a potent, nonpeptidic human immunodeficiency virus (HIV) protease inhibitor, suppresses a wide spectrum of HIV-1, HIV-2, and various clinical HIV-1 strains with IC50 of 0.3-5.5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	562.68
Formula	C28H38N2O8S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester

References

1. Yoshimura K, et al. J Virol. 2002 Feb;76(3):1349-58.

2. Ghosh, A. K., et al. 1998. Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorg. Med. Chem. Lett. 8:687–690.

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TMC-126 (UIC-94003, TMC126)

Biological Activity

Physicochemical Properties

References

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