Catalog No.: PC-42807Not For Human Use, Lab Use Only.
TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC50 of 9.9, shows activity against groups A and B RSV and against a panel of clinical isolates with equal potency (EC50<0.1 ng/mL).
TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC50 of 9.9, shows activity against groups A and B RSV and against a panel of clinical isolates with equal potency (EC50<0.1 ng/mL); binds at a hydrophobic pocket of the 6HB formed by amino acid residues from both HR1 and HR2 heptad-repeats, stabilizes the interaction of HR1 and HR2 in an alternate conformation of the 6HB; demonstrates in vivo activity in the cotton rat models, significantly reduces viral load, bronchoalveolar lavage cell accumulation and the severity of lung histopathological change at dose of 0.25-10 mg/Kg.
