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Chemical Structure : TMC353121
CAS No.: 857066-90-1
Catalog No.: PC-42807Not For Human Use, Lab Use Only.
TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC50 of 9.9, shows activity against groups A and B RSV and against a panel of clinical isolates with equal potency (EC50<0.1 ng/mL).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $125 | In stock | |
| 25 mg | $385 | In stock | |
| 100 mg | $825 | In stock | |
| 500 mg | Get quote |
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TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC50 of 9.9, shows activity against groups A and B RSV and against a panel of clinical isolates with equal potency (EC50<0.1 ng/mL); binds at a hydrophobic pocket of the 6HB formed by amino acid residues from both HR1 and HR2 heptad-repeats, stabilizes the interaction of HR1 and HR2 in an alternate conformation of the 6HB; demonstrates in vivo activity in the cotton rat models, significantly reduces viral load, bronchoalveolar lavage cell accumulation and the severity of lung histopathological change at dose of 0.25-10 mg/Kg.
| M.Wt | 558.7143 | |
| Formula | C32H42N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Pyridinol, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl- |
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1. Bonfanti JF, et al. J Med Chem. 2008 Feb 28;51(4):875-96.
2. Roymans D, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):308-13.
3. Rouan MC, et al. Antimicrob Agents Chemother. 2010 Nov;54(11):4534-9.
4. Ispas G, et al. PLoS One. 2015 May 26;10(5):e0126959.
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