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Chemical Structure : TMEM16A blocker 1PBC
Catalog No.: PC-49192Not For Human Use, Lab Use Only.
1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM).
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1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM).
1PBC inhibits WT TMEM16A with micromolar range potentcy (IC50=13.1 uM), mutants R617A and R784A confers greater potency to 1PBC compared with the WT (IC50, 2.2 and 5.8 uM).
1PBC binds with an apparent valence of ~0.27 and a Kd of ~3.6 µM at zero mV.
| M.Wt | 277.206 | |
| Formula | C13H6F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Christian J Peters, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3547-52.
2. Andy K M Lam, et al. Nat Commun. 2022 May 19;13(1):2798.
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