Chemical Structure : TMLB-C16
CAS No.:
2923531-50-2
TMLB-C16
(B3GAT3 inhibitor)
Catalog No.: PC-22571Not For Human Use, Lab Use Only.
TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells.
TMLB-C16 inhibits proliferation and migration, and induces cell cycle arrest and apoptosis in MHCC-97H (IC50= 6.53 μM) and HCCLM3 (IC50= 6.22 μM) cells.
TMLB-C16 demonstrated favorable pharmacokinetic properties with a relatively high bioavailability of 68.37%.
TMLB-C16 significantly inhibited tumor growth in both MHCC-97H and HCCLM3 xenograft tumor models without causing obvious toxicity.
Physicochemical Properties
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M.Wt
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453.88
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Formula
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C23H20ClN3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 3-(2-((1-(2-chloro-4-methylphenyl)-2-oxopyrrolidin-3-yl)amino)-2-oxoacetyl)-1H-indole-5-carboxylate
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References
1. Hao Yin, et al. J Med Chem. 2024 Jun 25. doi: 10.1021/acs.jmedchem.4c00242.
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