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Chemical Structure : TMLB-C16
Catalog No.: PC-22571Not For Human Use, Lab Use Only.
TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells.
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TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells.
TMLB-C16 inhibits proliferation and migration, and induces cell cycle arrest and apoptosis in MHCC-97H (IC50= 6.53 μM) and HCCLM3 (IC50= 6.22 μM) cells.
TMLB-C16 demonstrated favorable pharmacokinetic properties with a relatively high bioavailability of 68.37%.
TMLB-C16 significantly inhibited tumor growth in both MHCC-97H and HCCLM3 xenograft tumor models without causing obvious toxicity.
| M.Wt | 453.88 | |
| Formula | C23H20ClN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hao Yin, et al. J Med Chem. 2024 Jun 25. doi: 10.1021/acs.jmedchem.4c00242.
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