Chemical Structure : TMP-316
CAS No.:
TMP-316
(TMP316, BPN-0037316)
Catalog No.: PC-28395Not For Human Use, Lab Use Only.
TMP-316 (BPN-0037316) is a selective inhibitor of protein kinase A, G and C (AGC) family with cell-free Kd of 1.1 nM and 0.017 nM for S6K1 and ROCK2, shows high selectivity against the broader kinome.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TMP-316 (BPN-0037316) is a selective inhibitor of protein kinase A, G and C (AGC) family with cell-free Kd of 1.1 nM and 0.017 nM for S6K1 and ROCK2, shows high selectivity against the broader kinome.
TMP-316 docks into the ATP-binding cleft of all four representatives (ROCK2, S6K1, PKX, PKCγ) with a similar type I binding pose engaging conserved hinge, G-rich, and DFG-in residues.
TMP-316 remodels neuronal signaling to drive neurite outgrowth.
TMP-316 (0.3 or 1 mg/kg) promotes locomotor recovery in a rat cervical hemicontusion model.
Physicochemical Properties
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M.Wt
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476.51
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Formula
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C26H25FN4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((3R,4R)-4-(4-(3-ethyl-2-fluoro-6-hydroxybenzoyl)benzamido)pyrrolidin-3-yl)isonicotinamide
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References
1. Al-Ali H, et al. bioRxiv [Preprint]. 2026 Sep 7:2026.08.28.746753.
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