Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TMP195
CAS No.: 1314891-22-9
Catalog No.: PC-60293Not For Human Use, Lab Use Only.
TMP-195 is a first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TMP195 is a first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively.
TMP195 shows no significant inhibition for others HDACs.
TMP195 alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes in mice.
TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours.
| M.Wt | 456.42 | |
| Formula | C23H19F3N4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide |
|
1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.
2. Guerriero JL, et al. Nature. 2017 Mar 16;543(7645):428-432.
3. Cassetta L, et al. Cell Res. 2017 Aug;27(8):963-964.
4. Groselj B, et al. Mol Cancer Ther. 2017 Aug 24. pii: molcanther.0011.2017.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
