Chemical Structure : TN-2
CAS No.:
2983719-82-8
TN-2
(Tubulin/NRP1 inhibitor TN-2)
Catalog No.: PC-21448Not For Human Use, Lab Use Only.
TN-2 is a potent, dual tubulin/NRP1-targeting inhibitor with IC50 of 0.71 uM (tubulin polymerization) and 0.85 uM (NRP-1), inhibits proliferation and angiogenesis of tumor cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TN-2 is a potent, dual tubulin/NRP1-targeting inhibitor with IC50 of 0.71 uM (tubulin polymerization) and 0.85 uM (NRP-1), inhibits proliferation and angiogenesis of tumor cells.
TN-2 significantly inhibits the viability of several human prostate tumor cell lines.
TN-2 inhibits tubulin polymerization and cause G2/M arrest, thereby inducing cell apoptosis.
TN-2 also suppress cell tube formation, migration, and invasion.
TN-2 shows obvious antitumor effects on the PC-3 cell-derived xenograft model with negligible side effects and good pharmacokinetic profiles.
Physicochemical Properties
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M.Wt
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571.63
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Formula
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C28H37N5O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(Z)-(4-((2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)amino)-4-oxobutanoyl)-L-arginine
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References
1. Lufeng Zheng, et al. Journal of Medicinal Chemistry. 2023.
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