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Chemical Structure : TNFR1 inhibitor FKC
Catalog No.: PC-22074Not For Human Use, Lab Use Only.
TNFR1 inhibitor FKC is an allosteric inhibitor targets TNFR1 (Tumor necrosis factor receptor 1), inhibits TNFR1 activation by altering the conformational states of the receptor dimer without blocking receptor-ligand interaction or disrupting receptor dimerization.
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TNFR1 inhibitor FKC is an allosteric inhibitor targets TNFR1 (Tumor necrosis factor receptor 1), inhibits TNFR1 activation by altering the conformational states of the receptor dimer without blocking receptor-ligand interaction or disrupting receptor dimerization.
FKC binds to TNFR1 cysteine-rich domains (CRD2/3) and perturbs the conformational dynamics required for receptor activation.
FKC increases the frequency in the opening of both CRD2/3 and CRD4 in the receptor dimer, as well as induces a conformational opening in the cytosolic regions of the receptor.
FKC impedes the recruitment of downstream signaling molecules of TNFR1.
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| Appearance | Solid | |
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10 mM in DMSO |
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1. Jialiu Zeng, et al. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2308132121.
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