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Chemical Structure : TNF inhibitor TIM1c
Catalog No.: PC-49446Not For Human Use, Lab Use Only.
TNF inhibitor TIM1c is an orally active small molecule inhibitor of TNF, potently inhibit TNF-induced cell death and cytokine secretion, prevents homotrimerization of TNF by directly binding to the TNF monomer with SPR KD of 1.55 and 0.68 uM for rmTNF and rhTNF, respectively.
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TNF inhibitor TIM1c is an orally active small molecule inhibitor of TNF, potently inhibit TNF-induced cell death and cytokine secretion, prevents homotrimerization of TNF by directly binding to the TNF monomer with SPR KD of 1.55 and 0.68 uM for rmTNF and rhTNF, respectively.
TNF inhibitor TIM1c stably occupies the TNF homodimer through nonpolar interactions.
TNF inhibitor TIM1c displays negligible cytotoxicity and great inhibition of TNF-driven induction of IL-8 and IL-6 in human dermal fibroblasts.
TNF inhibitor TIM1c (20 mg/kg) showed oral bioactivity in a mouse model of collagen-induced polyarthritis (CIA) and suppressed arthritis symptoms, reduces IL-1β and IL-6 immunopositive cells.
TNF inhibitor TIM1c is a specific and potent disruptor of TNF homotrimerization.
| M.Wt | 436.534 | |
| Formula | C22H24N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Javaid N, et al. Sci Signal. 2022 Nov 8;15(759):eabi8713.
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