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Chemical Structure : TNFα-IN-C87
CAS No.: 332420-90-3
Catalog No.: PC-42239Not For Human Use, Lab Use Only.
A novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $446.4 | In stock | |
| 100 mg | $798.4 | In stock |
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A novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities; effectively attenuates TNFα-induced inflammation in a murine acute hepatitis model.
| M.Wt | 502.9323 | |
| Formula | C24H15ClN6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 9.33 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(4-chloro-3-nitrophenyl)hydrazone] |
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1. Ma L, et al. J Biol Chem. 2014 May 2;289(18):12457-66.
2. Chen S, et al. J Chem Inf Model. 2017 May 22;57(5):1101-1111.
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