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TNFα-IN-C87

Chemical Structure : TNFα-IN-C87

CAS No.: 332420-90-3

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TNFα-IN-C87 (TNFα inhibitor C87, C 87)

Catalog No.: PC-42239Not For Human Use, Lab Use Only.

TNFα-IN-C87 (C 87) is a novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities.

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5 mg $68 In stock
10 mg $98 In stock
25 mg $158 In stock
50 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TNFα-IN-C87 (C 87) is a novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities.
TNFα-IN-C87 effectively attenuates TNFα-induced inflammation in a murine acute hepatitis model.

Physicochemical Properties

M.Wt 502.9323
Formula C24H15ClN6O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 9.33 mg/mL
Chemical Name/SMILES

1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(4-chloro-3-nitrophenyl)hydrazone]

References

1. Ma L, et al. J Biol Chem. 2014 May 2;289(18):12457-66.

2. Chen S, et al. J Chem Inf Model. 2017 May 22;57(5):1101-1111.

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