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TNIK inhibitor OBD9

Chemical Structure : TNIK inhibitor OBD9

CAS No.: 2099064-75-0

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TNIK inhibitor OBD9 (OBD9)

Catalog No.: PC-49469Not For Human Use, Lab Use Only.

OBD9 is a small molecule TNIK inhibitor that blocks Wnt/beta-catenin signaling at the final step of transcriptional activation, suppresses colorectal cancer growth by interfering with the Wnt signaling pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OBD9 is a small molecule TNIK inhibitor that blocks Wnt/beta-catenin signaling at the final step of transcriptional activation, suppresses colorectal cancer growth by interfering with the Wnt signaling pathway.
    OBD9 induces autophagic degradation of TNIK (traf2 and Nck-interacting kinase), which promotes T-cell factor-4 (TCF4)/beta-catenin–mediated gene expression.

    Physicochemical Properties

    M.Wt 380.40
    Formula C20H20N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl (5-(4-(methyl(oxetan-3-yl)amino)benzoyl)-1H-benzo[d]imidazol-2-yl)carbamate

    References

    1. Zhou K, et al. Mol Cancer Ther. 2022 Oct 27:MCT-21-0801.
    2. Jae Eun Cheong, et al. Eur J Med Chem. 2018 Jan 20:144:372-385.

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