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Chemical Structure : TNIK inhibitor X
CAS No.: 933886-36-3
Catalog No.: PC-36010Not For Human Use, Lab Use Only.
TNIK inhibitor X is a potent inhibitor of Traf2- and Nck-interacting kinase (TNIK) (in vitro enzyme IC50=9 nM) with a reasonable selectivity over 30-folds against the majority of a panel of 50 kinases profiled.
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|---|---|---|---|
| 5 mg | $478 | In stock | |
| 10 mg | $758 | In stock | |
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| 100 mg | Get quote |
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TNIK inhibitor X is a potent inhibitor of Traf2- and Nck-interacting kinase (TNIK) (in vitro enzyme IC50=9 nM) with a reasonable selectivity over 30-folds against the majority of a panel of 50 kinases profiled.
TNIK inhibitor X inhibits cell viability of PAMC82 and T47D cells harboring TNIK amplification with IC50 of 1.77 and 0.385 uM, respectively.
TNIK inhibitor X shows no inhibitory activity against TNIK-non-amplified AZ-521 cells (IC50>30 uM).
TNIK inhibitor X suppresses pAKT and induction of LC3 in TNIK-amplified PAMC82 cells, shows minimal effects on either Wnt signaling-mediated transcription.
| M.Wt | 395.437 | |
| Formula | C19H17N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(4-acetamidobenzamido)-2-(phenylamino)thiazole-4-carboxamide |
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1. Yu DH, et al. Oncogenesis. 2014 Feb 24;2:e89.
2. Yamada T, et al. TNIK inhibitor and the use. W02010/064111A1.
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