TNKS-IN-41 |CAS:1584646-59-2 Probechem Biochemicals

Chemical Structure : TNKS-IN-41

TNKS-IN-41 (Tankyrase inhibitor 41)

Catalog No.: PC-60367Not For Human Use, Lab Use Only.

TNKS-IN-41 is a highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.

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Biological Activity

TNKS-IN-41 is a highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.
TNKS-IN-41 shows high selectivity over the other PARP family members.
TNKS-IN-41 induces growth inhibition of a number of tumor derived cell lines.

Physicochemical Properties

M.Wt	482.508
Formula	C24H22N10O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-Methyl-1H-pyrazol-3-yl)(4-(4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzoyl)piperazin-1-yl)methanone

References

1. Thomson DW, et al. J Med Chem. 2017 Jul 13;60(13):5455-5471.

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TNKS-IN-41 (Tankyrase inhibitor 41)

Biological Activity

Physicochemical Properties

References

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