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Chemical Structure : TNP-470
Catalog No.: PC-63314Not For Human Use, Lab Use Only.
TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis.
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TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis.
TNP-470 has anti-growth factor properties and inhibits the activation of Cdk 2 and phosphorylation of RB protein, inhibits potently PDGF- and bFGF-stimulated proliferation of rat mesangial cells in vitro (IC50 = 50 pg/ml).
TNP-470 inhibits tumor growth and metastasis of rodent tumors.
TNP-470 does not bind to or inhibit MetAP-1.
| M.Wt | 401.884 | |
| Formula | C19H28ClNO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamaoka M, et al. Cancer Res. 1993 Sep 15;53(18):4262-7.
2. Haraguchi M, et al. Kidney Int. 1997 Jun;51(6):1838-46.
3. Garrabrant T, et al. Angiogenesis. 2004;7(2):91-6.
4. Ingber D, et al. Nature. 1990 Dec 6;348(6301):555-7.
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