Catalog No.: PC-63314Not For Human Use, Lab Use Only.
TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis.
TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis.
TNP-470 has anti-growth factor properties and inhibits the activation of Cdk 2 and phosphorylation of RB protein, inhibits potently PDGF- and bFGF-stimulated proliferation of rat mesangial cells in vitro (IC50 = 50 pg/ml).
TNP-470 inhibits tumor growth and metastasis of rodent tumors.
TNP-470 does not bind to or inhibit MetAP-1.
