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Chemical Structure : TOFA
CAS No.: 54857-86-2
Catalog No.: PC-42306Not For Human Use, Lab Use Only.
TOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $128 | In stock | |
| 100 mg | $188 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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TOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis.
TOFA (RMI14514, MDL14514) is converted to TOFyl-CoA, exerts an allosteric inhibition on ACCA.
TOFA (RMI14514, MDL14514) lowers blood lipids and inhibits fatty acid synthesis with minimal effects on liver weight and liver fat content.
TOFA (RMI14514, MDL14514) also induces human cancer cell apoptosis through disturbing their fatty acid synthesis.
| M.Wt | 324.45498 | |
| Formula | C19H32O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
2-Furancarboxylic acid, 5-(tetradecyloxy)- |
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1. Parker RA, et al. J Med Chem. 1977 Jun;20(6):781-91.
2. McCune SA, et al. J Biol Chem. 1979 Oct 25;254(20):10095-101.
3. Wang C, et al. Biochem Biophys Res Commun. 2009 Jul 31;385(3):302-6.
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