TP-10 is a potent, selective inhibitor of cyclic nucleotide phosphodiesterase PDE10A with IC50 of 0.8 nM. increases the responsiveness of striatal neurons to electrical stimulation of the ipsilateral frontal cortex. TP-10 also increases cortically evoked spike activity in a stimulus intensity- and dose-dependent manner. TP-10 administration increased the incidence of antidromically activated (i.e., SNr+) MSNs.
