TPC2 inhibitor SC-3

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Chemical Structure : TPC2 inhibitor SC-3

Catalog No.: PC-27094Not For Human Use, Lab Use Only.

SC-3 is a synthesized tetrandrine-derived small-molecule inhibitor of two-pore channel 2 (TPC2), directly suppresses TPC2 activity enhanced by O-glycan truncation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SC-3 is a synthesized tetrandrine-derived small-molecule inhibitor of two-pore channel 2 (TPC2), directly suppresses TPC2 activity enhanced by O-glycan truncation.
SC-3 robustly inhibited both basal and TPC2-A1-N–stimulated inward currents in whole-lysosomal patch-clamp recordings in glycosylation-deficient THP-1 cells.
SC-3 directly attenuates TPC2 conductance independently of the permeant ion species.

Physicochemical Properties

M.Wt	624.78
Formula	C38H44N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(benzyloxy)-4-methoxybenzyl)-6,7-dimethoxy-8-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline

References

1. Lin A, et al. Nat Commun. 2026 Jun 10. doi: 10.1038/s41467-026-74268-6.

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