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TPN729

Chemical Structure : TPN729

CAS No.: 936951-20-1

TPN729 (TPN 729)

Catalog No.: PC-63028Not For Human Use, Lab Use Only.

TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TPN729 (TPN-729) is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.
TPN729 selectively inhibits PDE5 and blocks the degradation of cyclic guanosine monophosphate, and is a promising PDE5 inhibitor providing fewer side effects and better compliance.

Physicochemical Properties

M.Wt 516.661
Formula C25H36N6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-methyl-4-propoxy-N-[2-(1-pyrrolidinyl)ethyl]benzenesulfonamide

References

1. Wang Z, et al. J Sex Med. 2013 Nov;10(11):2790-7.

2. Zhu Y, et al. J Pharm Biomed Anal. 2016 Jan 5;117:217-26.

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