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TPN729 maleate

Chemical Structure : TPN729 maleate

CAS No.: 1422955-52-9

TPN729 maleate (TPN 729)

Catalog No.: PC-63029Not For Human Use, Lab Use Only.

TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM.
    TPN729 shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.
    TPN729 selectively inhibits PDE5 and blocks the degradation of cyclic guanosine monophosphate, and is a promising PDE5 inhibitor providing fewer side effects and better compliance.

    Physicochemical Properties

    M.Wt 632.73
    Formula C29H40N6O8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-methyl-4-propoxy-N-[2-(1-pyrrolidinyl)ethyl]-, (2Z)-2-butenedioate (1:1)

    References

    1. Wang Z, et al. J Sex Med. 2013 Nov;10(11):2790-7.

    2. Zhu Y, et al. J Pharm Biomed Anal. 2016 Jan 5;117:217-26.

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