TPN729 maleate |CAS:1422955-53-0 Probechem Biochemicals

Chemical Structure : TPN729 maleate

TPN729 maleate (TPN 729)

Catalog No.: PC-63029Not For Human Use, Lab Use Only.

TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM.

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Biological Activity

TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM.
TPN729 shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.
TPN729 selectively inhibits PDE5 and blocks the degradation of cyclic guanosine monophosphate, and is a promising PDE5 inhibitor providing fewer side effects and better compliance.

Physicochemical Properties

M.Wt	632.73
Formula	C29H40N6O8S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-methyl-4-propoxy-N-[2-(1-pyrrolidinyl)ethyl]-, (2Z)-2-butenedioate (1:1)

References

1. Wang Z, et al. J Sex Med. 2013 Nov;10(11):2790-7.

2. Zhu Y, et al. J Pharm Biomed Anal. 2016 Jan 5;117:217-26.

TPN729 maleate (TPN 729)

Biological Activity

Physicochemical Properties

References

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