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Chemical Structure : TR-14035
CAS No.: 232271-19-1
Catalog No.: PC-44703Not For Human Use, Lab Use Only.
A potent, orally bioavailable, dual α4β7/α4β1 integrin antagonist with IC50 of 7/87 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $304 | In stock | |
| 50 mg | $720 | In stock | |
| 100 mg | $1120 | In stock |
Bulk size, bulk discount!
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A potent, orally bioavailable, dual α4β7/α4β1 integrin antagonist with IC50 of 7/87 nM; blocks the binding of human α4β7 to an (125)I-MAdCAM-Ig fusion protein with IC50 of 0.75 nM; suppresses antigen-induced lung interleukin (IL)-5 mRNA upregulation, inhibits the leukocyte rolling flux, adhesion and emigration induced by IL4 in rats.
Asthma
Phase 1 Discontinued
| M.Wt | 474.3333 | |
| Formula | C24H21Cl2NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO：≥ 41 mg/mL |
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| Chemical Name/SMILES |
[1,1'-Biphenyl]-4-propanoic acid, α-[(2,6-dichlorobenzoyl)amino]-2',6'-dimethoxy-,(αS)- |
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1. Sircar I, et al. Bioorg Med Chem. 2002 Jun;10(6):2051-66.
2. Cortijo J, et al. Br J Pharmacol. 2006 Mar;147(6):661-70.
3. Tsuda-Tsukimoto M, et al. Pharm Res. 2006 Nov;23(11):2646-56.
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