Chemical Structure : TR120
CAS No.:
1072879-22-1
TR120
(TR 120, TR-120)
Catalog No.: PC-20633Not For Human Use, Lab Use Only.
TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
TR120 is a potent inductor of apoptosis in the BCR-ABL-positive K562 and KCL-22 cell lines and in their imatinib resistant counterpart K562-R and KCL22-R cells in vitro.
TR120 induces a marked decrease in signal transducer and activator of transcription 5 (STAT5) expression in K562 cells.
TR120 exhibits synergistic effects when used in combination with imatinib in both sensitive and resistant cells.
Physicochemical Properties
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M.Wt
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525.30
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Formula
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C21H20INO7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(NC1=C(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)OC3=CC(OC)=CC=C13)CI
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References
1. Romagnoli R, et al. Eur J Med Chem. 2016 Jan 27;108:39-52.
2. Grimaudo S, et al. Anticancer Drugs. 2013 Apr;24(4):384-93.
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