TREX1-IN-3

Chemical Structure : TREX1-IN-3

Catalog No.: PC-26959Not For Human Use, Lab Use Only.

TREX1-IN-3 (Compound 95) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM, and has EC50 for HCT116 cells of < 1 μM.

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Biological Activity

TREX1-IN-3 (Compound 95) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM, and has EC50 for HCT116 cells of < 1 μM.

Physicochemical Properties

M.Wt	490.90
Formula	C24H19ClN6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(((2-chlorophenyl)(3-cyanophenyl)methyl)(methyl)amino)-5-hydroxy-N-(isoxazol-4-yl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

References

1. Patent WO2021016317 A1, Pyrimidinediones as modulators of TREX1 and their preparation. Compound 95.

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TREX1-IN-3

Biological Activity

Physicochemical Properties

References

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