TRK inhibitor 19k

Chemical Structure : TRK inhibitor 19k

CAS No.: 2758623-12-8

Catalog No.: PC-22476Not For Human Use, Lab Use Only.

TRK inhibitor 19k is a potent, selective pan tropomyosin receptor kinase (pan-TRK) inhibitor with IC50 of 23/25/21 nM for TRKA/B/C, respectively.

Packing	Price	Stock
5 mg	$358	In stock
10 mg	$548	In stock
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100 mg		Get quote

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Biological Activity

TRK inhibitor 19k is a potent, selective pan tropomyosin receptor kinase (pan-TRK) inhibitor with IC50 of 23/25/21 nM for TRKA/B/C, respectively.
TRK inhibitor 19k inhibited the proliferation (IC50=0.15 uM) and induced the apoptosis of Km-12 cells.
TRK inhibitor 19k inhibited the phosphorylation of TRK to block downstream pathways.

Physicochemical Properties

M.Wt	454.93
Formula	C23H24ClFN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[5-Chloro-4-[[(3-fluorophenyl)methyl]amino]-2-pyrimidinyl]amino]-N-(3R)-3-piperidinylbenzamide

References

1. Tianxiao Wu, et al. Eur J Med Chem. 2022 Feb 15:230:114096.

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