Chemical Structure : TROX-1
CAS No.:
1309601-26-0
TROX-1
(TROX 1;TROX1)
Catalog No.: PC-60679Not For Human Use, Lab Use Only.
TROX-1 is a potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TROX-1 is a potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM).
TROX-1 inhibits omiga-conotoxin GVIA-sensitive calcium currents with greater potency under depolarized conditions (IC50=0.4 uM) in rat DRG neurons, blocks all Ca(v)2 family channels.
TROX-1 reduces nociception in preclinical pain models, while sparing normal cardiac and behavioral functions.
Physicochemical Properties
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M.Wt
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434.859
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Formula
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C22H16ClFN6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3R)-5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1H-1,2,4-triazol-3-yl)-1,3-dihydro-2H-indol-2-one
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References
1. Abbadie C, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55.
2. Swensen AM, et al. Mol Pharmacol. 2012 Mar;81(3):488-97.
3. Patel R, et al. Neuroscience. 2015 Jun 25;297:47-57.
4. Rahman W, et al. Neuroscience. 2015 Oct 1;305:76-85.
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