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Chemical Structure : TROX-1
Catalog No.: PC-60679Not For Human Use, Lab Use Only.
TROX-1 is a potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM).
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TROX-1 is a potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM).
TROX-1 inhibits omiga-conotoxin GVIA-sensitive calcium currents with greater potency under depolarized conditions (IC50=0.4 uM) in rat DRG neurons, blocks all Ca(v)2 family channels.
TROX-1 reduces nociception in preclinical pain models, while sparing normal cardiac and behavioral functions.
| M.Wt | 434.859 | |
| Formula | C22H16ClFN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Abbadie C, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55.
2. Swensen AM, et al. Mol Pharmacol. 2012 Mar;81(3):488-97.
3. Patel R, et al. Neuroscience. 2015 Jun 25;297:47-57.
4. Rahman W, et al. Neuroscience. 2015 Oct 1;305:76-85.
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