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Chemical Structure : TSPO agonist CB34
Catalog No.: PC-60733Not For Human Use, Lab Use Only.
TSPO agonist CB34 is a potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively.
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TSPO agonist CB34 is a potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively.
TSPO agonist CB34 does not show any affinity for central benzodiazepine receptors, has little or no marked effects on GABA-evoked Cl- currents.
TSPO agonist CB34 induces a dose-dependent increase in the concentrations of neuroactive steroids in plasma and brain, stimulate brain steroidogenesis in vivo.
| M.Wt | 438.777 | |
| Formula | C21H22Cl3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Serra M, et al. Br J Pharmacol. 1999 May;127(1):177-87.
2. Mitsui K, et al. Neuropharmacology. 2015 Dec;99:51-66.
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