Chemical Structure : TSWV inhibitor Z9
CAS No.:
TSWV inhibitor Z9
Catalog No.: PC-24208Not For Human Use, Lab Use Only.
TSWV inhibitor Z9 is a small molecule inhibitor of tomato spotted wilt virus (TSWV) nucleocapsid protein (N), targets N protein (KD=7.6 uM) to inhibit the replication level of the viral ribonucleoprotein (RNP).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TSWV inhibitor Z9 is a small molecule inhibitor of tomato spotted wilt virus (TSWV) nucleocapsid protein (N), targets N protein (KD=7.6 uM) to inhibit the replication level of the viral ribonucleoprotein (RNP).
Z9 is a compound with broad-spectrum antiviral activity against plant viruses. decreases N protein condensation in plant cells.
Z9 significantly disrupts the formation of inclusion bodies (IBs).
Z9 is capable of interacting with the amino acids in the nucleic acid binding region of TSWV N, disrupting the assembly of N and RNA into phase-separated condensates, the reduction of which is detrimental to the stability of the N protein.
Physicochemical Properties
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M.Wt
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445.60
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Formula
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C22H27N3O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(dimethylamino)propyl (E)-4-(3-(4-oxo-4H-chromen-3-yl)acryloyl)piperazine-1-carbodithioate
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References
1. Zan N, et al. Nat Commun. 2025 Feb 27;16(1):2034.
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