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Chemical Structure : TT-10
CAS No.: 2230640-94-3
Catalog No.: PC-35820Not For Human Use, Lab Use Only.
TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes.
TT-10 promotes cardiomyocyte proliferation and simultaneously exerts antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway.
TT-10 ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice.
| M.Wt | 283.339 | |
| Formula | C11H10FN3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2-(allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone |
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1. Hara H, et al. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653.
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