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TT-OAD2

Chemical Structure : TT-OAD2

CAS No.: 1246826-07-2

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TT-OAD2

Catalog No.: PC-72212Not For Human Use, Lab Use Only.

TT-OAD2 is a potent, selective, non-peptide agonist of glucagon-like peptide-1 (GLP-1) receptor with EC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TT-OAD2 is a potent, selective, non-peptide agonist of glucagon-like peptide-1 (GLP-1) receptor with EC50 of 5 nM.
    TT-OAD2 inhibited GLP-1- and oxyntomodulin-mediated cAMP, calcium, pERK1/2 and β-arrestin responses in a concentration-dependent manner.
    TT-OAD2 exhibits biased agonism, and kinetics of G-protein activation and signalling that are distinct from peptide agonists.

    Physicochemical Properties

    M.Wt 856.841
    Formula C50H47Cl2N3O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-((3S,8S)-3-(4-((3,4-dichlorobenzyl)oxy)phenyl)-7-((S)-1-phenylpropyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carboxamido)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propanoic acid

    References

    1. Zhao P, et al. Nature. 2020 Jan;577(7790):432-436.

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