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TTK21

Chemical Structure : TTK21

CAS No.: 709676-56-2

TTK21 (CBP-p300 activator TTK21)

Catalog No.: PC-36166Not For Human Use, Lab Use Only.

TTK21 (CBP-p300 activator TTK21) is a small molecule activator of CBP/p300 histone acetyltransferase activity with a maximal effect at a concentration of 275 uM.

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Biological Activity

TTK21 (CBP-p300 activator TTK21) is a small molecule activator of CBP/p300 histone acetyltransferase activity with a maximal effect at a concentration of 275 uM.
TTK21 induces acetylation of histones H3 and H4 in vitro but not H2B and H2A.
TTK21 promotes neurogenesis and extends memory duration in adult mice, promotes regeneration and sprouting of sensory and motor axons, as well as recovery of sensory and motor functions in both the mouse and rat model of spinal cord injury.

Physicochemical Properties

M.Wt 357.757
Formula C17H15ClF3NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-chloro-3-trifluoromethyl-phenyl)-2-N-propoxy-benzamide

References

1. Chatterjee S, et al. J Neurosci. 2013 Jun 26;33(26):10698-712.

2. Hutson TH, et al. Sci Transl Med. 2019 Apr 10;11(487). pii: eaaw2064.

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