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TTP-8307

Chemical Structure : TTP-8307

CAS No.: 950225-08-8

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TTP-8307 (TTP8307)

Catalog No.: PC-62922Not For Human Use, Lab Use Only.

TTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses, targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses, targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 uM.
3A mutations V45A, I54F, and H57Y confer resistance to TTP-8307.

Physicochemical Properties

M.Wt 436.49
Formula C27H21FN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(1R)-1-(4-Fluorophenyl)ethyl]-3-[2-(isoquinolin-3-yl)-1H-imidazol-4-yl]benzamide

References

1. De Palma AM, et al. Antimicrob Agents Chemother. 2009 May;53(5):1850-7.

2. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.

3. Norder H, et al. Antiviral Res. 2011 Mar;89(3):204-18.

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