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TTP399

Chemical Structure : TTP399

CAS No.: 859525-02-3

TTP399 (Cadisegliatin, TTP-399, TTP 399)

Catalog No.: PC-36020Not For Human Use, Lab Use Only.

Cadisegliatin (TTP399) is a hepatoselective, oral Glucokinase (GK) activator with EC50 of 304 nM and 762 nM for human GK at high glucose concentration (15 mM) and normoglycemia (5 mM), respectively.

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Biological Activity

Cadisegliatin (TTP399) is a hepatoselective, oral Glucokinase (GK) activator with EC50 of 304 nM and 762 nM for human GK at high glucose concentration (15 mM) and normoglycemia (5 mM), respectively.
TTP399 increases GK activity in the liver without affecting the physiological role of GK (active when plasma glucose concentrations are high and inactive at low/normal plasma glucose concentration).
TTP399 increases glucose metabolism in rat hepatocytes with EC50 2.39 and 2.64 uM in the presence of 15 mM glucose for lactate production and glycogen content, respectively.
TTP399 improves glycemic control in both animal models of type 2 diabetes and patients with type 2 diabetes.

Physicochemical Properties

M.Wt 455.63
Formula C21H33N3O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((2-(3-cyclohexyl-3-((1r,4r)-4-propoxycyclohexyl)ureido)thiazol-5-yl)thio)acetic acid

References

1. Vella A, et al. Sci Transl Med. 2019 Jan 16;11(475). pii: eaau3441.

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