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Chemical Structure : TUG-1375
CAS No.: 2247372-59-2
Catalog No.: PC-35695Not For Human Use, Lab Use Only.
TUG-1375 (TUG1375, TUG 1375) is a potent, selective free fatty acid receptor 2 (FFA2/GPR43) agonist with β-arrestin-2 pEC50 of 6.1 and cAMP pEC50 of 7.11.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $158 | In stock | |
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
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TUG-1375 (TUG1375, TUG 1375) is a potent, selective free fatty acid receptor 2 (FFA2/GPR43) agonist with β-arrestin-2 pEC50 of 6.1 and cAMP pEC50 of 7.11.
TUG-1375 also shows activity on the murine FFA2 orthologue (pEC50=6.44 in the cAMP assay), displays no significant agonist or antagonist response in FFA1 (GPR40) or FFA4 (GPR120), or in nuclear receptors PPARα, PPARγ, PPARδ, LXRα or LXRβ.
TUG-1375 induces migration of human neutrophils and inhibits lipolysis in murine adipocytes.
| M.Wt | 442.542 | |
| Formula | C22H19ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,4R)-2-(2-Chlorophenyl)-3-(4-(3,5-dimethylisoxazol-4-yl)benzoyl)thiazolidine-4-carboxylic acid |
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1. Hansen AH, et al. J Med Chem. 2018 Sep 24. doi: 10.1021/acs.jmedchem.8b00855.
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