TUG-2304 | FFA2 (GPR43) antagonist | Probechem Biochemicals

Chemical Structure : TUG-2304

TUG-2304 (TUG2304)

Catalog No.: PC-20767Not For Human Use, Lab Use Only.

TUG-2304 (TUG2304) is a highly potent FFA2 (GPR43) antagonist with IC50 of 3-4 nM in both cAMP and GTPγS assays.

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Biological Activity

TUG-2304 (TUG2304) is a highly potent FFA2 (GPR43) antagonist with IC50 of 3-4 nM in both cAMP and GTPγS assays.
TUG-2304 completely inhibits propionate-induced neutrophil migration and respiratory burst in vivo.

Physicochemical Properties

M.Wt	419.41
Formula	C20H20F3N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(1H-tetrazol-5-yl)-3-(4-(trifluoromethyl)phenyl)propan-2-yl)-2-(3-methoxyphenyl)acetamide

References

1. Alice Valentini, et al. J Med Chem. 2023 May 11;66(9):6105-6121.

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TUG-2304 (TUG2304)

Biological Activity

Physicochemical Properties

References

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