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TUG-424

Chemical Structure : TUG-424

CAS No.: 1082058-99-8

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TUG-424 (TUG424)

Catalog No.: PC-20421Not For Human Use, Lab Use Only.

TUG-424 (TUG424) is a potent, selective free fatty acid receptor 1 (FFA1, GPR40) agonist with EC50 of 32 nM, TUG-424 (100 nM) enhances glucose-stimulated insulin secretion from rat INS-1E cells and isolated mouse islets.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TUG-424 (TUG424) is a potent, selective free fatty acid receptor 1 (FFA1, GPR40) agonist with EC50 of 32 nM, TUG-424 (100 nM) enhances glucose-stimulated insulin secretion from rat INS-1E cells and isolated mouse islets.

Physicochemical Properties

M.Wt 264.32
Formula C18H16O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[2-(2-Methylphenyl)ethynyl]benzenepropanoic acid

References

1. Christiansen E, et al. J Med Chem. 2008 Nov 27;51(22):7061-4.

2. Moodaley R, et al. Br J Pharmacol. 2017 Dec;174(23):4508-4522.

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