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Chemical Structure : TUG-891
CAS No.: 1374516-07-0
Catalog No.: PC-42283Not For Human Use, Lab Use Only.
TUG-891 is a potent, selective human GPR120 (FFA4) agonist with pEC50 of 7.22.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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TUG-891 is a potent, selective human GPR120 (FFA4) agonist with pEC50 of 7.22.
TUG-891 displays 288-fold more potent than hFFA1.
TUG-891 stimulates GLP-1 secretion from enteroendocrine cells, enhances glucose uptake in 3T3-L1 adipocytes, and inhibitis release of proinflammatory mediators from RAW264.7 macrophages.
TUG-891 inhibits LPA- and EGF-induced proliferation and migration in DU145 and PC-3 cells.
| M.Wt | 364.4094432 | |
| Formula | C23H21FO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzenepropanoic acid, 4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]- |
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1. Shimpukade B, et al. J Med Chem. 2012 May 10;55(9):4511-5.
2. Hudson BD, et al. Mol Pharmacol. 2013 Nov;84(5):710-25.
3. Liu Z, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):380-94.
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