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TVB-2640

Chemical Structure : TVB-2640

CAS No.: 1399177-37-7

TVB-2640 (Denifanstat, TVB2640)

Catalog No.: PC-72346Not For Human Use, Lab Use Only.

TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM, inhibits lipogenesis with therapeutic potential against NAFLD, nonalcoholic steatohepatitis, and KRAS MUT solid tumors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM, inhibits lipogenesis with therapeutic potential against NAFLD, nonalcoholic steatohepatitis, and KRAS MUT solid tumors.

Physicochemical Properties

M.Wt 439.563
Formula C27H29N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

>500 mM in DMSO (>220 mg/mL)

Chemical Name/SMILES

4-(1-(4-Cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl)piperidin-4-yl)benzonitrile

References

1. Syed-Abdul MM, et al. Hepatology. 2020 Jul;72(1):103-118.

2. Singh S, et al. Mini Rev Med Chem. 2020;20(18):1820-1837.

3. Loomba R, et al. Gastroenterology. 2021 Nov;161(5):1475-1486.

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