Chemical Structure : TVB-2640
CAS No.:
1399177-37-7
TVB-2640
(Denifanstat, TVB2640)
Catalog No.: PC-72346Not For Human Use, Lab Use Only.
TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM.
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| 50 mg | $588 | In stock | |
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
TVB-2640 (Denifanstat, TVB2640) is a first-in-class, potent, selective, oral fatty acid synthase (FASN) inhibitor with IC50 of 52 nM.
TVB-2640 (Denifanstat, TVB2640) inhibits lipogenesis with therapeutic potential against NAFLD, nonalcoholic steatohepatitis, and KRAS MUT solid tumors.
Physicochemical Properties
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M.Wt
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439.563
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Formula
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C27H29N5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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>500 mM in DMSO (>220 mg/mL)
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Chemical Name/SMILES
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4-(1-(4-Cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl)piperidin-4-yl)benzonitrile
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References
1. Syed-Abdul MM, et al. Hepatology. 2020 Jul;72(1):103-118.
2. Singh S, et al. Mini Rev Med Chem. 2020;20(18):1820-1837.
3. Loomba R, et al. Gastroenterology. 2021 Nov;161(5):1475-1486.
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