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Chemical Structure : TW-37
CAS No.: 877877-35-5
Catalog No.: PC-42836Not For Human Use, Lab Use Only.
TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities.
TW-37 potently inhibits cell growth in PC-3 prostate cancer cells with an IC(50) value of 200 nM and effectively induces apoptosis in a dose-dependent manner.
TW-37 shows antiangiogenic effect against endothelial cells (IC50=1.8 uM) with no cytotoxic effects for fibroblasts.
TW-37 induces endothelial cell apoptosis by mitochondrial depolarization and activation of caspase-9 and caspase-3, decreases the density of functional human microvessels in mouse model of human angiogenesis.
| M.Wt | 573.6991 | |
| Formula | C33H35NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]- |
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1. Ashimori N, et al. Mol Cancer Ther. 2009 Apr;8(4):893-903.
2. Wang Z, et al. Cancer Res. 2009 Apr 1;69(7):2757-65.
3. Zeitlin BD, et al. Cancer Res. 2006 Sep 1;66(17):8698-706.
4. Wang G, et al. J Med Chem. 2006 Oct 19;49(21):6139-42.
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