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TX2-121-1

Chemical Structure : TX2-121-1

CAS No.: 1603845-42-6

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TX2-121-1

Catalog No.: PC-35752Not For Human Use, Lab Use Only.

TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor.
    TX2-121-1 induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization.
    TX2-121-1 induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM.

    Physicochemical Properties

    M.Wt 716.931
    Formula C42H52N8O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-(2-(4-(3-(3-acrylamido-4-phenoxyphenyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-4-(adamantan-1-yl)-2-methylbutanamide

    References

    1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12.

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