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TY-52156

Chemical Structure : TY-52156

CAS No.: 934369-14-9

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TY-52156 (TY52156)

Catalog No.: PC-21209Not For Human Use, Lab Use Only.

TY-52156 is a potent, selective S1P3 receptor antagonist with Ki of 110 nM.

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25 mg $198 In stock
50 mg $298 In stock
100 mg $488 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TY-52156 is a potent, selective S1P3 receptor antagonist with Ki of 110 nM.
TY-52156 preferentially inhibited the S1P-induced increase in [Ca2]i in S1P3-CHO rather than S1P1-, S1P2-CHO, and S1P4-Chem.
TY-52156 inhibited both the S1P-induced increase in [Ca(2+)](i) and Rho activation in human coronary artery smooth muscle cells.
TY-52156 inhibited FTY-720-induced S1P(3) receptor-mediated bradycardia in vivo.

Physicochemical Properties

M.Wt 364.27
Formula C18H19Cl2N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl- 2-butanone

References

1. Murakami A, et al. Mol Pharmacol. 2010 Apr;77(4):704-13.

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