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Chemical Structure : TYM-3-98
Catalog No.: PC-22536Not For Human Use, Lab Use Only.
TYM-3-98 is a potent, selective inhibitor of PI3Kδ (PI3Kdelta) with IC50 of 7.1 nM, highly selective over other PI3K isoforms at both molecular and cellular levels.
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TYM-3-98 is a potent, selective inhibitor of PI3Kδ (PI3Kdelta) with IC50 of 7.1 nM, highly selective over other PI3K isoforms at both molecular and cellular levels.
TYM-3-98 showed superior antiproliferative activity in several B-lymphoma cell lines compared with the approved first-generation PI3Kδ inhibitor idelalisib.
TYM-3-98 demonstrated a concentration-dependent PI3K/AKT/mTOR signaling blockage followed by apoptosis induction.
TYM-3-98 showed good pharmaceutical properties and remarkably reduced tumor growth in a human lymphoma xenograft model and a mouse lymphoma model.
| M.Wt | 592.05 | |
| Formula | C28H23ClFN7O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lou SY, et al. Life Sci. 2024 Jun 15;347:122662.
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