Chemical Structure : TYM-3-98
CAS No.:
2820244-59-3
TYM-3-98
(PI3Kδ inhibitor)
Catalog No.: PC-22536Not For Human Use, Lab Use Only.
TYM-3-98 is a potent, selective inhibitor of PI3Kδ (PI3Kdelta) with IC50 of 7.1 nM, highly selective over other PI3K isoforms at both molecular and cellular levels.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TYM-3-98 is a potent, selective inhibitor of PI3Kδ (PI3Kdelta) with IC50 of 7.1 nM, highly selective over other PI3K isoforms at both molecular and cellular levels.
TYM-3-98 showed superior antiproliferative activity in several B-lymphoma cell lines compared with the approved first-generation PI3Kδ inhibitor idelalisib.
TYM-3-98 demonstrated a concentration-dependent PI3K/AKT/mTOR signaling blockage followed by apoptosis induction.
TYM-3-98 showed good pharmaceutical properties and remarkably reduced tumor growth in a human lymphoma xenograft model and a mouse lymphoma model.
Physicochemical Properties
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M.Wt
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592.05
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Formula
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C28H23ClFN7O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(1-(6-chloro-1-(3-(methylsulfonyl)phenyl)-1H-indazol-3-yl)ethyl)-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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References
1. Lou SY, et al. Life Sci. 2024 Jun 15;347:122662.
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