Chemical Structure : TYY-31
CAS No.:
TYY-31
Catalog No.: PC-26587Not For Human Use, Lab Use Only.
TYY-31 is a potent, highly selective sphingosine-1-phosphate receptor 3 (S1PR3) agonist with EC50 of 1.13 pM, with minimal activity against S1PR2/3/5 (EC50 >10 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TYY-31 is a potent, highly selective sphingosine-1-phosphate receptor 3 (S1PR3) agonist with EC50 of 1.13 pM, with minimal activity against S1PR2/3/5 (EC50 >10 uM).
TYY-31 triggered S1PR1 internalization in a concentration-dependent manner with EC50 of 0.73 nM, Emax =102.3%.
TYY-31 promoted ERK1/2 phosphorylation in a concentration-dependent manner.
TYY-31 effectively ameliorating dextran sulfate sodium-induced colitis in mice at a dose of 0.3 mg/kg.
TYY-31 demonstrated excellent cardiac safety characteristics in zebrafish-based assays.
Physicochemical Properties
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M.Wt
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487.54
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Formula
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C27H26FN5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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cis-3-((2-ethyl-4-(5-(4-(5-fluoropyrazin-2-yl)-3-methylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)amino)cyclobutane-1-carboxylic acid
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References
1. Ye T, et al. J Med Chem. 2026 Apr 17. doi: 10.1021/acs.jmedchem.5c03837.
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